(Scientific Reports, 2021) reported that NNMT inhibition plus a lean-diet substitution lowered body weight, fat mass, and liver fat beyond either intervention alone
Dose ranges come from allometric scaling (using a math formula to translate a mouse mg/kg dose into a human dose) and from research community use
5-Amino-1MQ has good oral absorption based on cell-uptake testing (Neelakantan 2018), and the typical 50 to 150 mg dose is far too large to inject comfortably
How a researcher divides it depends entirely on reconstitution
No human clinical trials have been published
This protein has an effect on cellular senescence and apoptosis, and it interacts with other proteins and signaling pathways to regulate gene expression, affecting cellular responses to stress, DNA repair, and cell survival