Williams reported that while central blockade of the GLP-1 system with ICV administration of exendin 939 blocked the actions of central but not peripheral GLP-1, peripheral (intraperitoneal) exendin 939 blocked the appetite-suppressing actions of peripheral, but not central GLP-1, indicating that the two systems do not depend on each other for activity
doi: 10.1186/s12933-021-01417-0 7 DruckerDJ
No, GLP-1 drugs are not addictive
GLP-1s can slow gastric emptying, helping patients feel fuller for longer periods, which can reduce overall calorie intake
However, the best drug is always the one that is right for your individual health profile, medical history, and goals not the one with the highest headline number
The issue with restrained eating is that it requires a constant conscious effort