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More than one-third of T2DM patients with myocardial infarction (MI) die within 10 years, and long-term all-cause mortality and cardiovascular mortality are even higher in younger patients than in elderly patients (Singh et al., 2020

The mild increase in DNA fragmentation at 200 g/mL is consistent with the elevated necrosis at that concentration: membrane disruption exposes chromatin to extracellular nucleases and divalent metal ions, accelerating fragmentation independently of ROS 51

In chronic consumers, its half-life can reach up to 12 days, which means it may be detectable for several weeks after use stops

Aldeyra has already submitted a Special Protocol Assessment for a crossover clinical trial and expects to hear FDA feedback on the plan in December

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