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Tirzepatide as a novel therapeutic option for patients with type 2 diabetes: a pooled analysis of subgroups of SURPASS 15 trials

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Blockade of IL-10 with a neutralizing antibody fully inhibited exenatide-induced -endorphin expression both in vitro and in vivo, effectively abolishing its mechanical antiallodynic effects in neuropathic rats [63]

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The inclusion of a 9mg dose tier is noteworthy because it was not tested in Phase 2