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Routes that Bypass First-Pass Metabolism: Sublingual (e.g., nitroglycerin) Intravenous (IV) Rectal (partial) Transdermal patches Clinical Significance: Important when dosing oral medications to achieve therapeutic effect

Medical conditions such as pernicious anemia and gastrointestinal disorders like Crohn's disease may interfere with the human body's ability to absorb vitamin B12

Chem 2013, 85 (23), 1157611584

reported that neither the selective deletion of beta-cell GCGR signaling nor incubation with a glucagon receptor antagonist, abolished glucagon-induced insulin secretion from isolated mouse islets (6)

Neurology | Handbook of Neurosurgery [Internet]