In the 5xFAD mouse model of AD, exendin-4 reduced the expression of Drp1 and increased that of OPA1 and Mfn2 [163]
NAD+ is a naturally occurring molecule found in every cell of the body, and it plays a crucial role in producing cellular energy, supporting metabolic function, and maintaining overall resilience
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Further, ascorbic acid being a strong antioxidant effectively inhibits the formation of lipid peroxides as ascorbic acid forms the first line of antioxidant defense mechanism in human plasma
It has also shown success in Phase II trials for ophthalmic repair and dry eye
The risk of switch to mania in patients with bipolar disorder during treatment with an antidepressant alone and in combination with a mood stabilizer