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Refinement and manual model building were performed with REFMAC 68 and coot 69 , respectively, using the ccp4i2 70 interface

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As indicated in the section titled Cysthathione -Synthase and Cystathionine -lyase Activity and Longevity in the Amino Acid Biosynthesis page, H 2 S functions as a gasotransmitter that relaxes vascular smooth muscle cells resulting in vasodilation

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Animal experiments show that pyridoxine treatment increases the resistance of nigral dopaminergic neurons to MPTP-induced neurotoxicity in wild-type mice as well as in astrocytic Drd2 conditional knockout mice