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DHODH is a flavin-dependent protein, present in the inner mitochondrial membrane, that converts DHO to orotate, reducing ubiquitin to pantothenol and producing lipophilic antioxidants, which inhibits LPO accumulation and ferroptosis (46)

Eur J Med Res 29(1):322 Keijer J et al (2024) Omics biomarkers and an approach for their practical implementation to delineate health status for personalized nutrition strategies

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This analysis revealed a strong correlation between the two protocols, as indicated by a correlation coefficient of 0.9991

Amino Acids (2012) 42(1):23146