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GIPR agonism supports glucose-dependent insulin release and lipid metabolism, while GCGR activation is linked to increased energy expenditure, hepatic lipolysis, and thermogenesis processes that together distinguish it from earlier incretin-based research compounds such as semaglutide and tirzepatide

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Statistical significance was assessed by ordinary One-Way ANOVA followed by Dunnetts multiple comparisons test in b , c , d

Safety and clinical effectiveness of GLP1 receptor agonists in inflammatory bowel disease patients

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