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The improper disposal of pharmaceutical wastes ranging from expired drugs and hospital effluents to residues from drug manufacturing, introduces complex chemical compounds into the ecosystem, with consequences for both environmental and public health [106]

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In contrast, we found that these metabolomic alterations led to a reduction in the plasma level of different metabolites including uridine, thymine, carnosine, theophylline, aspartate, taurine, serine, glutamate, tryptophan, arginine, and 53 other metabolites in the acute patients compared to HCs ( Supplementary Figures 6A, B )