It's also a good idea to chat with your doctor before starting if you have any pre-existing medical conditions, especially kidney disease, or if you've been advised to follow a protein-restricted diet
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That slowdown signals metabolic adaptation, and that is when a second agent with a different mechanism provides the most benefit
Parkinson disease patients have reduced SCFA-producing bacteria and increased LPS-producing Gram-negative bacteria in the gut, changes that may promote -synuclein aggregation and neuroinflammation (Sampson et al., 2016)
The profiles are fundamentally different: Surgical risks: 1-5% serious complication rate, anesthesia risk, infection, blood clots, staple line leaks (0.5-1%), increased GERD/acid reflux, lifelong nutritional deficiency risk, rare mortality (0.05-0.1%)
