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Treatment typically follows a gradual dose escalation schedule to allow the body to adjust and minimise side effects

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In paired secretagogue models, concurrent GHRH and GHRP activation has been shown to produce synergistic growth hormone release, reflecting two functionally distinct pathways that converge at the level of pituitary output

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We herein highlight some timely gaps and recommendations based on limited available evidence and expert opinion to help guide clinicians in addressing real-world questions raised in practice