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Glioblastoma therapy can be augmented by targeting IDH1-mediated NADPH biosynthesis

But it also regulates the immune response, for example in the production of cytokinesCytokines are small proteins produced by the immune system, which bind to specific receptors present on the cell membrane and communicate to the cell a specific set of instructions such as, for example, the stimulus to grow, or to differentiate or even the order to die

Bartoszewski et al

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However, emerging studies have shown that DAMPs that originate from neighbouring cells, and even from distal tissues or organs, also mediate sterile inflammatory responses