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Kang H, Kim KH, Lim J, Kim YS, Heo J, Choi J, Jeong J, Kim Y, Kim SW, Oh YM, Choo MS, Son J, Kim SJ, Yoo HJ, Oh W, Choi SJ, Lee SW, Shin DM

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Skipping dose steps dramatically increases the risk and severity of adverse events

Given the reduced glutamine levels observed in the MMA group, lower NAAD may reflect impaired glutamine-dependent NAD + synthesis rather than a primary defect in NAD metabolism