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However, systemic administration is hindered by poor blood-brain barrier (BBB) permeability, dose-limiting toxicity, and poor patient compliance due to frequent dosing regimens

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However, the consistent decrease in NF-B following treatment with Ru II 20a and Ru II 20b demonstrated the compounds modulatory capacity across all exposure stages (Figure 13)

they experience a resurgence in inflammation, blood pressure and cholesterol

Phenylalanine (Phe) Phenylalanine was first isolated from a natural source (lupine sprouts) in 1879 and subsequently synthesized chemically in 1882