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Sermorelin stimulation preserves negative feedback loops mediated by IGF-1, somatostatin, and other factors, creating a self-limiting system that helps prevent excessive GH production and associated risks like acromegaly-like symptoms, severe insulin resistance, or fluid retention

Terracciano, A

Aging compromises human islet beta cell function and identity by decreasing transcription factor activity and inducing ER stress

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Therefore, PBMC mtDNA should be considered a useful but limited biomarker, whose interpretation ought to be integrated with histological, imaging, or neurophysiological evidence (104, 136, 137)

Furthermore, patients with major depression show a reduced number of Tregs in their peripheral blood, a characteristic also associated with inflammatory diseases [511]