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Genetic associations with longevity are on average stronger in females than in males

Mechanistically, it has been observed that GSTP1-1 binds, in its monomeric form, both c-Jun and JNK, thus forming an heterotrimeric complex that inhibits the phosphorylation of c-Jun by JNK

The study also found that glutathione levels began to return to baseline approximately one month after supplementation ceased, indicating that consistent use is key to maintaining optimal levels

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