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Surprisingly, patients on these lower doses experienced weight loss comparable to those on the full dose of 3.0 mg, with average weight reductions of 7.4, 7.8, 9.0 and 8.0 kg for dosages of 1.2, 1.8, 2.4 and 3.0 mg, respectively (130)
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Structure-function analysis of class I and class II GRXs have shown that a conserved five amino acid long loop located between a highly conserved lysine residue and Cys A is the major determinant that interferes with oxidoreductase activity 14,15
We identified a homozygous point mutation in the GPX4 gene, resulting in an R152H coding mutation, in three patients with Sedaghatian-type spondylometaphyseal dysplasia
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