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Subsequently, AIM2 can be delivered in an IFN-I-dependent manner, leading to the upregulation of its downstream proteins, pyrin and ZBP1
Mechanistically, HGF-induced synapse formation is mediated by PI-3K and not MAPK activation, as inhibition of the PI-3K/AKT pathway affects synaptogenesis, while blocking MAPK/ERK does not decrease synapse density and only affects dendritic growth (Peng et al., 2016)
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In these studies, the dietary habits of omnivorous mammals closely resembled those of humans consuming mixed diets, whereas herbivorous feeding patterns showed similarities to plant-based dietary regimens in humans (67)