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The Takeaway Twenty-six percent is a massive weight loss number, and suggests that Mounjaro truly might earn its reputation as the King Kong of GLP-1s, assuming its FDA approval process for weight loss goes as Lilly intends.

In this episode John and Professor Shah open with why insulin alone has structural limitations in type 1 diabetes, work through how GLP-1 therapies act on the body, and then walk the trial evidence from the early exenatide and liraglutide studies to the more recent semaglutide and tirzepatide data

Atashi F, Modarressi A, Pepper MS

Constipation was a huge problem for me

These high prices create significant barriers for patients who could benefit from these life-changing treatments

At Gomori staining all fibers were gray, implying reticulin and collagen type 3 fibers (Figure 10), and positive collagen type 1 fibers were obtained using polarized microscopy Sirus red staining (Figure 11)