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Obesity causes organ dysfunction via several pathophysiological mechanisms, ranging from the physical impact of increased adipose tissue mass, the presence of ectopic fat within tissues and organs, metabolic effects, inflammatory mechanisms, and psychological consequences [4,5]
Nauck M, Frid A, Hermansen K, et al, for LEAD-2 Metformin Study Group
However, many insurance plans still exclude weight-loss drugs entirely, even if they are FDA-approved
10.1371/journal.pone.0061965 59 SirohiS.SchurdakJ
Phase 2 MRI-PDFF data showed a 22.2% absolute reduction in liver fat fraction at the 12 mg dose [2]
Tirzepatide and health-related quality of life in adults with obesity or overweight: results from the SURMOUNT-3 phase 3 randomized trial
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