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doi:10.1016/S0140-6736(22)02033-5 Evidence-Base Disclosure The published evidence base for Retatrutide GLP-3 consists predominantly of preclinical research animal models (often rats or mice) and in vitro cell-culture experiments

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The BBB, similar to the peripheral vasculature, is susceptible to degradation and dysfunction of endothelial cells through oxidative stress, inflammation, and mechanical hemodynamic stress (i.e., high systolic pressures and pulsatility) (Moyaert et al., 2023

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PMID: 35975308