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doi: 10.1210/jcem.80.3.7883856 33 DruckerDJNauckMA

52 Contraindications GLP-1RAs are contraindicated in patients with a personal or family history of medullary thyroid carcinoma or in patients with multiple endocrine neoplasia syndrome type 2

Moreover, it is increasingly recognized that weight loss itself primarily serves as a surrogate marker for favorable changes in body fat distribution, particularly reductions in ectopic fat depots such as visceral adipose tissue and intrahepatic lipid content, both of which are strongly associated with ASCVD risk (80, 81)

doi: 10.1016/j.physbeh.2011.02.030 17 RoperSD

Important Context When Interpreting GLP-1 Clinical Trials Each of these clinical trials was conducted separately using different study designs, patient populations, and treatment protocols

They also help support long-term firmness by maintaining skin integrity at the cellular level