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Retatrutide clinical trial data Retatrutide data comes primarily from two sources: a Phase 2 trial published in the New England Journal of Medicine and the Phase 3 TRIUMPH program that began reporting results in mid-2025

Receptor mechanism and downstream signalling

Greb D, Hebeisen M, Matter A, Opitz I, Lauk O

It should not be used as a meal replacement

doi: 10.1093/jnci/94.6.437 277

34 Unfortunately, we lacked systematic access to glycated haemoglobin values, which could have indicated that cases in our study population were with well-managed diabetes inadvertently selected leading to a rate of birth defects similar to the general population