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Nutrients 11 (2019)

The dominant adverse events in both are gastrointestinal nausea, diarrhea, vomiting, and constipation and in both they are dose-dependent and tend to ease as the body adapts to gradual dose escalation

Charlesworth M, Wiles MD

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Exposure to sugars induces rapid GLP-1 secretion from T1R3-sensitive cells, following a dose-dependent pattern where higher stimulus concentrations lead to greater secretionan effect blocked by GLP-1 receptor antagonists (61, 67)