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The peptide chains unfold, aggregate, and form structures that no longer match the active conformation required for biological activity

lactis HN019 supplementation on colonic transit time and gastrointestinal symptoms in adults with functional constipation: A double-blind, randomized, placebo-controlled, and dose-ranging trial

Du J, Yang Q, Sun Y, Shi P, Xu H, Chen X, et al

The significance of this lies in the fact that Clostridiales are widely acknowledged as beneficial microorganisms and are inversely linked with metabolic disorders [88]

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When food reaches the digestive tract, GLP-1 sends messages throughout the body that help coordinate how nutrients are processed