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At a glance FDA-approved GLP-1 indications / chronic weight management in adults with BMI 30 or BMI 27 with a weight-related comorbidity STEP 1 weight loss / 14.9% mean reduction at 68 weeks with semaglutide 2.4 mg vs

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Thus, after ligand binding, the insulin-IR complex is internalized, followed by degradation of the ligand and either degradation, recycling, or translocation of the receptor to other intracellular sites (2325)

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