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C-terminal amidation, as seen in Nle-Tyr-Ile-His-NH, also provided a more modest increase in stability

[Abstract]2022;2429:127-142

Previous AngIV analogs, while showing promise in animal models of dementia, were hindered by poor metabolic stability indicated by a short half-life, and an inability to cross the BBB due to their peptide nature

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80 L of each plasma sample is transferred to previously prepared tubes containing 240 L of ice-cold acetonitrile and vortexed vigorously

It is extensively studied in preclinical models for its ability to promote dendritic spine formation, enhance synaptic plasticity, and support neuronal regeneration