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It helps avoid dehydration, a common side effect from the drugs effect on digestive fluids

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Starting Dose : 2.5 mg once weekly for the first four weeks Increasing Dose : After four weeks, the dose may increase to 5 mg once weekly

Geometric means [coefficient of variation (CV), %] for AUC showed no consistent trend with decreasing renal function, ranging from a lowest exposure of 2567 nmol h/L (18%) in the ESRD group to a highest exposure of 3179 nmol h/L (22%) in the severe RI group

Whilst the NHS notes that taking up to 2,000 micrograms daily is unlikely to cause harm in most people, there is generally no benefit to consuming such excessive amounts unless treating confirmed deficiency under medical supervision