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Mitochondria serve as the primary intracellular source of ROS and emanate from electron leakage within the respiratory ETC

They're quite small right now, but I'm not sure what to do about them

10.1021/acs.bioconjchem.0c00525 16 LiY.ChenH.VooL

In addition, angiopoietin 2 and placental growth factor , which are associated with tumor angiogenesis, induce macrophage polarization toward the M2 phenotype, thereby leading to the development of an immunosuppressive TME 72