In addition, site-directed quantitative coupling of the TLR7/8 agonist imidazoquinolone IMDQ to a single-chain antibody fragment can not only target TAMs by targeting macrophage mannnose receptors (MMRs) on TAMs, but also inhibit tumor growth by promoting TAMs repolarization to a pro-inflammatory phenotype (43)
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172 The senescent cells are not replaced after removal but instead disturb the blood-tissue barrier, leading to fibrosis of the liver and perivascular tissues
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