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doi: 10.1016/j.numecd.2021.05.010 14 Action to Control Cardiovascular Risk in Diabetes Study GroupGersteinHCMillerMEByingtonRPGoffDCBiggerJTet al

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The aggregation is due to the folding of the amyloids in a way that causes similar nearby ones to fold in a similar way a process akin to the propagation of prion amyloids in mad-cow disease and in its human counterpart, Creutzfeldt-Jakob disease (Goedert, 2015

5-Amino-1MQ (5-amino-1-methylquinolinium) is a selective, cell-permeable inhibitor of nicotinamide N-methyltransferase (NNMT)