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We applied a recently validated long-acting GIPR antagonist 23 , which prevented glucose lowering in response to an acylated GIPR agonist in wild-type mice (Extended Data Fig

Exclusion criteria observed in Phase 2 trials included individuals with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2, given the class-level concern with GLP-1 receptor agonists and C-cell tumours in rodent models [8]

Many protocols combine routes, using systemic delivery for immune modulation and topical delivery for direct plaque treatment

Research protocols typically call for 2-5 mg per administration during loading phases