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doi: 10.1111/1471-0307.12286 194 Plaza-DiazJRuiz-OjedaFJGil-CamposMGilA

M.MurphyK.et al

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Additionally, analysis reveals that drug development timelines are lengthening, with the average time from Phase 1 clinical trials to regulatory submission exceeding 100 months

In other words, instead of forming a single rigid complex, MLO formation involves multiple, individually weak interaction sites that are constantly associating and dissociating