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Hyperglycemia can inhibit autophagy activity in proximal tubular cells by activating mTOR Complex 1 (mTORC1), a nutrient status sensor involved in cell growth, development and proliferation (105)

J Clin Med 9(4):920 Albakri A (2019) RASopathy-associated cardiomyopathy

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However, it was shown to have counter-regulatory attenuating role on GHS-R1a signaling, possibly via the formation of heterodimers with GHS-R1a (332)

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