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## Head-to-Head Comparison Table | Feature | Orforglipron | Oral Semaglutide | Tirzepatide (Injectable) | |---------|-------------|-----------------|-------------------------| | **Drug type** | Non-peptide small molecule | Peptide with SNAC enhancer | Peptide (GLP-1/GIP dual agonist) | | **Route** | Oral (daily pill) | Oral (daily tablet) | Subcutaneous injection (weekly) | | **Weight loss** | ~15% (Phase 2/3 data) | ~15.1% (OASIS 1) | 20-22.5% (SURMOUNT-1) | | **Fasting required?** | No | Yes (30+ min empty stomach) | N/A (injection) | | **Food/water restrictions** | None | 4 oz water only

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doi: 10.3389/fendo.2022.1043789 [DOI] [PMC free article] [PubMed] [Google Scholar] 48