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10.1016/j.eclinm.2023.102191 49 HanN.LiL

This triple-G receptor approach may offer broader metabolic benefits, including improved energy expenditure and fat metabolism, although long-term safety and tolerability are still under investigation

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To circumvent this limitation and enable extended pharmacokinetic evaluations, Cagrilintide incorporates targeted structural modifications, including a fatty acid moiety (acylation) that facilitates reversible binding to plasma albumin