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15 Thus, both arms did achieve clinically meaningful within-group reductions in hemoglobin A1C, with the difference between groups failing to achieve that threshold

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Indeed, GLP-1 mimetics and inhibitors of DPP-4, an enzyme that renders GLP-1 and other proglucagon family members inactive, are now well-established therapeutic agents

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More recently, we also evidenced that starvation induced p38 MAPK activation, which by reprogramming glucose metabolism by the pentose phosphate pathway sustains NADPH production