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Apart from acetate, an important source of cytosolic acetyl-CoA is by cleavage of citrate that originated from mitochondria, catalyzed by ATP-citrate lyase 264,280,281

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Human Peroxiredoxin 6 is essential for malaria parasites and provides a host-based drug target

These findings suggest that LPS may trigger ferroptosis in granulosa cells through a dual mechanism involving suppression of the antioxidant defense system (GPX4) and disruption of iron metabolic homeostasis (via SLC7A11-mediated cystine uptake and ferritin-mediated iron storage)

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