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For kinetic experiments with fecal communities, fecal slurries prepared as described above were used instead of starter cultures

2017;67:387.e385

& Fowler, J

In dextran sulphate sodium (DSS)-induced colitis mice, the most commonly used preclinical IBD model, injected MOTS-c significantly reduced colon shortening and histological damage, lowered pro-inflammatory cytokines and plasma myeloperoxidase, and curbed macrophage and neutrophil activity

No entanto, importante notar que essas observaes provm exclusivamente de estudos animais e que os dados de segurana em humanos permanecem muito limitados

Glutathione transferase activity decreased in rheumatoid arthritis, which can be related to shortness of reduced glutathione developing during oxidative stress