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Currently, very little information is known regarding sensing of intracellular oxidative stress which elicits ROS-induced signaling to regulate the survival and antioxidant enzymes repertoire gene expression

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Lubik AA, Gunter JH, Hollier BG, Ettinger S, Fazli L, Stylianou N, et al

Individuals with G6PD deficiency are susceptible to hemolytic anemia when exposed to certain oxidative drugs, and Methylene Blue is one of them