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Heterozygotes (1 per 500 people) typically exhibit a 30% increase in the duration of skeletal muscle blockade after a standard dose of succinylchloline, whereas homozygotes (1 per 2000 to 5000 people) can experience 2-3 hours of neuromuscular blockade (Thomsen et al, 2015

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These findings demonstrate a previously unrecognized capacity of YPEL5 to recruit CTLH substrates and enable the discovery of MGDs for exceedingly common acidic and basic degrons

3), we monitored the presence of LC3-positive autophagosomes in cells depleted of TBC1D9B, ARL8A/B, or both proteins