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The risk is severe caloric restriction that drops below 800 to 1,000 calories per day, which triggers metabolic adaptation, muscle loss, nutrient deficiencies, and hormonal disruption

Weight loss can reduce the risk of developing these health problems but, despite this, levels of obesity remain high

Free Radic Res 2015;49:309-16

In clinical studies, liraglutide and semaglutide both led to an average 0.3-point drop in A1c in prediabetic participants (after 56 weeks for liraglutide 5 and 68 weeks for semaglutide 6 )a small but meaningful shift for people whose blood sugar is creeping upward toward the diabetes threshold

In simple terms: Capsules: easier, gut-focused, less direct systemic exposure Injections: more direct, stronger systemic exposure, more care required This does not mean one form is always better

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