sinha et al. liposomal glutathione eur j clin nutr 2018 is critical for NK cell-mediated immunity Enhancing glutathione delivery and efficacy:

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In contrast, non-cleavable linkersdue to their high stability in blood and normal tissuescan significantly reduce free drug concentrations, thereby lowering off-target toxicity

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a) VCit linker and b) EVCit linker structures [5] Additionally, VCit linkers are susceptible to cleavage by neutrophil elastase, which is implicated in clinical dose-limiting toxicities like neutropenia