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It is possible that the lack of bodyweight phenotype in some genetic models is related to developmental compensation or the redundant effects of multiple anorectic gut hormones on food intake

PMID 30246248

Non-biodegradable inorganic NPs (e.g., iron oxide, gold, silica) may accumulate in the liver, spleen, or lungs, potentially inducing chronic oxidative injury, granuloma formation, or fibrosis [481, 482]

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[9] In other words, cagrilintide revived a decades-old hormonal axis in a once-weekly, combination-ready form