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Adeoye O, Olawumi J, Opeyemi A, Christiania O

These polymorphisms are unrelated to cobalamin metabolism and the elevated MMA levels do not, by themselves, indicate a B12 deficiency (Molloy, 2016)

The mechanism appears to involve interaction with the endogenous opioid systemDSIP modulates enkephalin and beta-endorphin release, suggesting opioid-system cross-talk

Moreover, this trial was conducted at a private practice and published in an alternative medicine journal, again raising concerns about bias

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