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This compounds across a training cycle

Administration of insulin subcutaneously, including insulin glargine products, has resulted in lipoatrophy (depression in the skin) or lipohypertrophy (enlargement or thickening of tissue) in some patients [see Dosage and Administration (2.2)]

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For the subcutaneous formulation (Ozempic for diabetes, Wegovy for weight management), treatment typically begins at 0.25 mg once weekly for four weeks, then increases to 0.5 mg weekly

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The critical role of oxidative stress in sarcopenic obesity