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This participant was already taking tirzepatide when she enrolled in the trial, but before any stimulation was delivered, giving us a unique opportunity to make foundational observations about how the drug alters brain signals." At first, results were promising: As patient 3's tirzepatide levels reached full dosage, craving-linked NAc activity in her brain went dormant and she had no obsessive thoughts about food

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Similar to what has been described for GST, GT is also considered to be part of a resistance phenotype