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This review summarizes various molecular mechanisms including the role of checkpoint inhibitors that can be harnessed to develop effective therapeutic strategies for targeting ROS related signaling in cancer

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28 Human mtDNA is composed of 16,569 bases encoding 37 genes, including 13 genes coding for peptides forming the oxidative phosphorylation (OXPHOS) system, 2 ribosomal RNA genes (12S and 16S), and 22 tRNAs (Figure 2)

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