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Tirzepatide is administered as a once-weekly subcutaneous injection, with doses typically starting at 2.5 mg and gradually increasing by 2.5 mg every 4 weeks as tolerated to a maintenance dose ranging from 5 mg to 15 mg, depending on individual response and tolerability

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j , Representative images of intestinal NE morphology in NPP-1::GFP animals grown on EV or cco-1 RNAi bacteria with or without stearic acid (SA, C18:0, 5 mM) supplementation